Special NoticeActiveDARPA-SN-26-67

Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)

DEPT OF DEFENSE / DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) / DEF ADVANCED RESEARCH PROJECTS AGCY

Key dates?

Posted?: May 6, 2026
Response deadline?: Jun 24, 2026, 4:00 PM UTC
Archive date?: —
Archive type?: autocustom

Classification?

Notice type?: Special Notice
Base type?: Special Notice
Set-aside?: —
Set-aside code?: —
PSC?: AC11

NAICS?

541714Research and Development in Biotechnology (except Nanobiotechnology)

Issuing office?

Department?: DEPT OF DEFENSE
Sub-tier?: DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Office?: DEF ADVANCED RESEARCH PROJECTS AGCY
Office code?: 097.97AE.HR0011
Organization type?: OFFICE
Office address?: ARLINGTON, VA, 222032114, USA

Contacts?

Dr. Aric Lu, DARPA/BTOprimary
D-PECHE@darpa.mil (awards)

Description?

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. Mechanisms capable of modifying the epigenome offer new opportunities to control DNA-protein interactions and to study the functions and applications of rare or novel epigenetic modifications. This research opportunity will result in demonstrations of novel technologies to modify nucleic acids in vitro.

Attachments (1)?

📎 DARPA-SN-26-67.pdf
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Other notices in this solicitation?

Special NoticeResearch Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)May 18, 2026LATEST

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Metadata?

Notice ID?: 554a1250e7e44f8f8f9797eb40b5031b
Full path?: DEPT OF DEFENSE.DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA).DEF ADVANCED RESEARCH PROJECTS AGCY
Office code?: 097.97AE.HR0011
Ingested?: May 7, 2026
Updated?: Jun 25, 2026