US-FED-00000393354 - Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability (CADENCC) - Deadline September 17,2026

Agency: Department of the ArmyOffice: Army Contracting Command, Edgewood Contracting DivisionLocation: Fort Detrick, MD, USAProgram Office: Capability Program Executive for Chemical, Biological, Radiological and Nuclear Defense (CPE CBRN Defense), Joint Project Lead Enabling Technologies (JPL ET)RPP Number: W911SR–26–R–CADENCCDate Issued: 03 September 2026Proposals Due: 1500 hours, 17 September 20261. Through this Request for Project Proposal (RPP), the Capability Program Executive for Chemical, Biological, Radiological and Nuclear Defense`s (CPE CBRN Defense) Joint Project Lead Enabling Technologies (JPL ET) seeks to develop Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability (CADENCC), an enabling capability that will accelerate clinical trial startup through implementation of Master Protocols, innovative technologies that support decentralized trial operations and augment data collection and analysis, and establishment of a pre–positioned clinical trial site network enabling CBRN defense readiness as described in the attached Statement of Objectives (SOO). The Government is hereby requesting formal submission of preproposals to execute a formal agreement under 10 USC 4022, Other Transaction Authority (OTA) for the prototype project described below.Upon receipt of a preproposal submitted in response to this RPP, the next steps are as follows:The Government will evaluate the preproposal.Discussions among the parties, whether verbally or in writing, will occur as appropriate.The Government may request a full proposal from the offeror.Additional discussions will occur as necessary.Award may be made after evaluation and selection of a successful submission. (Note: Awards are dependent upon the availability of funds.)2. This RPP is issued to request project proposals in compliance with USC 4022 and is being issued for planning purposes only. It is not to be construed as a commitment by the Government to award an agreement, nor will the Government pay for the information solicited.3. The JPL ET enables the rapid development, manufacture, and fielding of safe and effective medical solutions across the full product spectrum, including development, clinical trials, manufacturing, and validated biological threat detection materials. The objective of Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability (CADENCC) is to develop an enabling capability that will accelerate clinical trial startup through implementation of Master Protocols, innovative technologies that support decentralized trial operations and augment data collection and analysis, and establishment of a pre–positioned clinical trial site network enabling CBRN defense readiness. CADENCC will primarily conduct Phase I/Phase II clinical trials for pre–exposure prophylaxis (PrEP), post–exposure prophylaxis (PEP), and early treatment products which may be under Animal Rule. Any resultant award may be issued as a prototype Agreement under the authority of 10 USC 4022, with the expectation that quantities necessary for production, including fielding and testing new capabilities, may be non–competitively procured from awarded to the successful performer(s) of a prototype project in a follow–on production contract or other transaction agreement.4. The Government will review/evaluate the submitted preproposals and if there is Government interest, the Agreements Officer may issue a request for full proposal (RFFP) in response to this RPP. The Government may award an agreement based on the submission or may require submission of additional details. The award of Prototype agreements shall be for the development of prototypes that are directly relevant to enhancing the mission effectiveness of personnel of the Department of Defense and the supporting platforms, systems, components, or materials proposed to be acquired or developed by the Department of Defense, or to improvement of platforms, systems, components, or materials in use by the Armed Forces. A prototype project can generally be described as a preliminary pilot, test, evaluation, demonstration, or agile development activity used to evaluate the technical or manufacturing feasibility or military utility of a particular technology, process, concept, end item, effect, or other discrete feature. Only a warranted Agreements Officer may obligate the U.S. Government to the expenditure of funds for awards under this Announcement.5. Evaluation will be performed by CPE–CBRND personnel, other Federal Agency Representatives, or combinations thereof to enable the selection of the best preproposal submission, and/or subsequent full proposal submission. After evaluation and selection, an award will be made to the successful offeror(s). Subsequent awards depend upon the availability of funds and fulfillment of requirements and priorities determined to exist at the time of award. In some cases, funding prio