Advancing Global Capacity to Detect and Respond to Fungal Diseases

This Notice of Funding Opportunity (NOFO) aims to support activities that build and strengthen sustainable fungal disease detection, diagnosis, surveillance, and response systems. Activities may address interconnected areas such as system and workforce development, laboratory and diagnostic capacity, and improved use of data to inform public health action. Through these efforts, this NOFO seeks to strengthen country and regional capacity to manage and control fungal diseases at their source while promoting long-term ownership and integration into public health systems. These efforts align with the priorities outlined in the America First Global Health Strategy by supporting country capacity to detect, respond to, and control priority fungal pathogens, particularly those that pose a risk for international spread and antifungal resistance, at their source. Over time, activities supported through this NOFO are intended to reduce the global burden of fungal diseases, strengthen health security, and help countries protect their own populations while also reducing risks to the United States through earlier detection and more effective response to fungal disease threats worldwide Eligibility: In addition to the general eligibility requirements, applicants must meet the following criteria to be considered for award:Demonstrated Oversight Capacity:Eligible organizations must demonstrate the institutional infrastructure and expertise necessary for effective program implementation and sound financial management. The applicant —not a third-party or sub-recipient — must serve as the primary lead for all activities and remain fully accountable for both programmatic and financial performance. This includes independently leading, managing, and monitoring technical interventions, as well as overseeing fiscal responsibilities such as budgeting, expenditure tracking, regulatory compliance, and financial reporting. While the CDC will provide technical guidance and ensure alignment with relevant legislative and regulatory requirements, applicants are expected to manage all day-to-day operations and reporting responsibilities.Responsiveness to Application Requirements:Applicants are also reminded that adherence to application instructions is critical. The CDC will consider an application as "non-responsive" if any required documents are missing or if the request exceeds $300,000. Applications that do not conform to the outlined submission requirements —including those that omit documentation, fail to follow formatting or content instructions, or request funding above the stated limit— will not be considered for review. Applicants are strongly encouraged to carefully review all guidance to ensure completeness and compliance prior to submission. Award ceiling: 0 CFDA: 93.318