TECHNOLOGY LICENSING OPPORTUNITY: 3-HP Upgrading Platform

This technology from Los Alamos National Laboratory, 3-HP Upgrading Platform, provides a novel, bio-based pathway to produce methyl methacrylate (MMA) by converting renewably producible 3-hydroxypropionic acid (3-HP) into a constituent substrate for normally petroleum-derived MMA. By operating directly on fermentation-derived 3-HP, the process reduces the need for costly puri?cation steps and improves overall production e?ciency. It also introduces a novel chemical intermediate formed during the reaction, o?ering additional di?erentiation. For manufacturers, this approach enables a more sustainable and potentially lower-cost route to a high-demand chemical used in plastics, coatings, adhesives and medical materials—without requiring changes to existing products or end-use applications. Overview: This invention is a chemical process for upgrading 3-hydroxypropionic acid (3-HP) into methyl methacrylate (MMA) using an integrated reactive extraction approach. In this system, 3-HP produced through fermentation is directly converted within a solvent phase, where extraction and chemical transformation occur simultaneously. This design improves reaction selectivity and enables more e?cient handling of aqueous fermentation streams compared to conventional multi-step methods. The process includes multiple novel reaction pathways—such as ester- and lactone-based routes—and generates a distinct intermediate during conversion. In addition to MMA production, the approach can be extended to other bio-based molecules, providing a broader platform for transforming biomass-derived feedstocks into industrial chemical intermediates. The Opportunity: The 3-HP Upgrading Platform presents licensees with an opportunity to enter or expand into the MMA market using a di?erentiated, bio-based production route that aligns with growing demand for sustainable materials. By enabling the conversion of renewably sourced 3-HP into a constituent substrate for normally petroleum-derived MMA, companies can reduce reliance on fossil feedstocks while maintaining compatibility with existing PMMA applications and supply chains. The process is particularly attractive for producers seeking to integrate upstream fermentation capabilities or diversify raw material inputs, o?ering a pathway to improve cost e?ciency and supply resilience. As end markets increasingly prioritize lower-carbon and bio-based content—across automotive, electronics, construction and medical sectors—this technology positions licensees to capture value through sustainable product o?erings without requiring changes to downstream manufacturing or product performance. Key Advantages: Bio-based production route reducing reliance on petroleum feedstocks Drop-in compatibility with existing MMA/PMMA applications and supply chains Direct use of fermentation streams, minimizing puri?cation requirements Improved process e?ciency through integrated reaction and extraction Novel conversion pathway from 3-HP to MMA, including a unique intermediate Alignment with sustainability goals and growing demand for greener materials Market Applications: Automotive (glazing, coatings, lightweight components) Electronics & Displays (screens, optical materials, housings) Construction & Infrastructure (panels, sealants, protective surfaces) Medical & Healthcare (devices, implants, coatings) Adhesives & Coatings (industrial coatings, ?nishes, bonding materials) Consumer & Industrial Plastics (transparent plastics, durable goods, 3D printing materials) Development Status: TRL 3 US Patent pending LA-UR-26-23337 LANL Tech Partnerships: Unlock the Innovative Potential Los Alamos National Laboratory o?ers a wide range of cutting-edge technologies and capabilities that may provide your company with a competitive edge in the market and unlock the innovative potential that can enhance, re?ne, and revolutionize your products. LANL’s licensing program focuses on moving inventions developed by our researchers to commercial innovations. Patented and patent pending inventions and copyrighted software are available to existing and start-up companies through exclusive and non-exclusive licensing agreements. For speci?c discussions, please contact licensing@lanl.gov. Note: This is not a call for external services for the development of this technology. https://www.lanl.gov/engage/collaboration/feynman-center/partner-with-us/licensing-technology m.lanl.gov/tech-search